Photosensitization caused by ibuprofen. [J Am Acad Dermatol. 1992]

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1: J Am Acad Dermatol. 1992 Jan;26(1):114-6.Links

Photosensitization caused by ibuprofen.

Bergner T, Przybilla B.

Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Federal Republic of Germany.

Several nonsteroid antiinflammatory drugs (e.g., benoxaprofen, carprofen, and piroxicam) are known to induce photosensitivity reactions, but this has not yet been documented for ibuprofen. We observed a photosensitivity reaction in a patient treated with an oral ibuprofen preparation. This patient had a lowered minimal erythema dose for UVA but not for UVB after oral administration of ibuprofen. Results of a photopatch test with the drug were negative. In vitro UVA irradiation of human erythrocytes in the presence of ibuprofen caused ultraviolet dose-dependent phototoxic hemolysis.

PMID: 1531054 [PubMed - indexed for MEDLINE]

Photopatch testing in seven cases of photosensitive drug eruptions. [Ann Pharmacother. 2001]
Phototoxicity of non-steroidal anti-inflammatory drugs: in vitro studies with visible light. [Acta Derm Venereol. 1996]
Propionic acid-derived non-steroidal antiinflammatory drugs are phototoxic in vitro. [Photodermatol. 1985]
[Photosensitizing properties of nonsteroidal antirheumatic drugs in the photopatch test] [Hautarzt. 1987]
Photosensitivity to piroxicam is induced by sensitization to thimerosal and thiosalicylate. [J Invest Dermatol. 1992]
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Photosensitization caused by ibuprofen.

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