Cell Tissue Res. 2004 Oct;318(1):261-73. Epub 2004 Aug 11.

Stem cell therapy for Parkinson's disease: where do we stand?

Roybon L, Christophersen NS, Brundin P, Li JY.

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Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, BMC A10, 22184 Lund, Sweden. laurent.roybon@mphy.lu.se

Abstract

A major neuropathological feature of Parkinson's disease (PD) is the loss of nigrostriatal dopaminergic neuron. Patients exhibit motor symptoms, including bradykinesia, rigidity, and tremor. Neural grafting has been reported to restore striatial dopaminergic neurotransmission and induce symptomatic relief. The major limitation of cell replacement therapy for PD is the shortage of suitable donor tissue. The present review describes the possible sources of cells, including embryonic stem cells and somatic adult stem cells, both of which potentially could be used in cell therapy for PD, and discusses the advantages and disadvantages of each cell type.

PMID:: 15309619; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

"NeuroStem Chip": a novel highly specialized tool to study neural differentiation pathways in human stem cells. [BMC Genomics. 2007]
"NeuroStem Chip": a novel highly specialized tool to study neural differentiation pathways in human stem cells.
Anisimov SV, Christophersen NS, Correia AS, Li JY, Brundin P. BMC Genomics. 2007 Feb 8; 8:46. Epub 2007 Feb 8.
Mesencephalic human neural progenitor cells transplanted into the neonatal hemiparkinsonian rat striatum differentiate into neurons and improve motor behaviour. [J Anat. 2006]
Mesencephalic human neural progenitor cells transplanted into the neonatal hemiparkinsonian rat striatum differentiate into neurons and improve motor behaviour.
Hovakimyan M, Haas SJ, Schmitt O, Gerber B, Wree A, Andressen C. J Anat. 2006 Dec; 209(6):721-32.

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