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Infect Dis Clin North Am. 2004 Sep;18(3):621-49, xi-.

Macrolides and ketolides: azithromycin, clarithromycin, telithromycin.

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  • 1Jefferson Medical College, Philadelphia, PA, USA. zuckermj@einstein.edu

Abstract

The advanced macrolides, azithromycin and clarithromycin, and the ketolide telithromycin are structural analogues of erythromycin. They have several distinct advantages when compared with erythromycin including enhanced spectrum of activity, more favorable pharmacokinetics and pharmacodynamics, once daily administration, and improved tolerability. This article reviews the pharmacokinetics, antimicrobial activity, clinical use, and adverse effects of these antimicrobial agents.

PMID:
15308279
[PubMed - indexed for MEDLINE]
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