Trends Cell Biol. 2004 Aug;14(8):461-9.

The role of profilin complexes in cell motility and other cellular processes.

Source

EMBL, Program for Mouse Biology, Campus Adriano Buzzati-Traverso, 00016 Monterotondo, Italy. witke@embl-monterotondo.it

Abstract

Profilins are small actin-binding proteins that are essential in all organisms that have been examined to date. In vitro, profilins regulate the dynamics of actin polymerization, which is their key role in vivo during cell motility. However, there is growing evidence that, apart from actin binding, profilins function as hubs that control a complex network of molecular interactions. Profilins interact with a plethora of proteins and the importance of this aspect of their function is just beginning to be understood. In this article, I will summarize recent findings in mammalian cells and mice, and discuss the evidence of a role for profilins in cellular processes such as membrane trafficking, small-GTPase signaling and nuclear activities, in addition to neurological diseases and tumor formation.

PMID:: 15308213; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

A crucial role for profilin-actin in the intracellular motility of Listeria monocytogenes. [EMBO Rep. 2003]
A crucial role for profilin-actin in the intracellular motility of Listeria monocytogenes.
Grenklo S, Geese M, Lindberg U, Wehland J, Karlsson R, Sechi AS. EMBO Rep. 2003 May; 4(5):523-9.
Review Profilin: at the crossroads of signal transduction and the actin cytoskeleton. [Bioessays. 1994]
Review Profilin: at the crossroads of signal transduction and the actin cytoskeleton.
Sohn RH, Goldschmidt-Clermont PJ. Bioessays. 1994 Jul; 16(7):465-72.
Profilin I is essential for cell survival and cell division in early mouse development. [Proc Natl Acad Sci U S A. 2001]
Profilin I is essential for cell survival and cell division in early mouse development.
Witke W, Sutherland JD, Sharpe A, Arai M, Kwiatkowski DJ. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3832-6. Epub 2001 Mar 13.
Tumor suppressor activity of profilin requires a functional actin binding site. [Mol Biol Cell. 2004]
Tumor suppressor activity of profilin requires a functional actin binding site.
Wittenmayer N, Jandrig B, Rothkegel M, Schlüter K, Arnold W, Haensch W, Scherneck S, Jockusch BM. Mol Biol Cell. 2004 Apr; 15(4):1600-8. Epub 2004 Feb 6.
Review Cell motility: proline-rich proteins promote protrusions. [Trends Cell Biol. 2001]
Review Cell motility: proline-rich proteins promote protrusions.
Holt MR, Koffer A. Trends Cell Biol. 2001 Jan; 11(1):38-46.

See reviews... See all...

Cited by 45 PubMed Central articles

Immunological Responses and Actin Dynamics in Macrophages Are Controlled by N-Cofilin but Are Independent from ADF. [PLoS One. 2012]
Immunological Responses and Actin Dynamics in Macrophages Are Controlled by N-Cofilin but Are Independent from ADF.
Jönsson F, Gurniak CB, Fleischer B, Kirfel G, Witke W. PLoS One. 2012; 7(4):e36034. Epub 2012 Apr 27.
Protein phosphatase 1 dephosphorylates profilin-1 at ser-137. [PLoS One. 2012]
Protein phosphatase 1 dephosphorylates profilin-1 at ser-137.
Shao J, Diamond MI. PLoS One. 2012; 7(3):e32802. Epub 2012 Mar 30.
Gene expression profiling of the cephalothorax and eyestalk in Penaeus monodon during ovarian maturation. [Int J Biol Sci. 2012]
Gene expression profiling of the cephalothorax and eyestalk in Penaeus monodon during ovarian maturation.
Brady P, Elizur A, Williams R, Cummins SF, Knibb W. Int J Biol Sci. 2012; 8(3):328-43. Epub 2012 Feb 9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The role of profilin complexes in cell motility and other cellular processes.
The role of profilin complexes in cell motility and other cellular processes.
Trends Cell Biol. 2004 Aug ;14(8):461-9.

PubMed
Diagnostic immunohistochemistry of neuroblastic tumors.
Diagnostic immunohistochemistry of neuroblastic tumors.
Am J Surg Pathol. 1992 Jan ;16(1):49-57.

PubMed
[Effects of DL-alpha-lipoic acid on the experimentally induced diabetic cataract...
[Effects of DL-alpha-lipoic acid on the experimentally induced diabetic cataract in rats].
Zhonghua Yan Ke Za Zhi. 2004 Mar ;40(3):193-6.

PubMed
A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with ad...
A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer.
J Clin Oncol. 1992 Jan ;10(1):111-6.

PubMed
Screening postmenopausal women for ovarian cancer: a systematic review.
Screening postmenopausal women for ovarian cancer: a systematic review.
J Obstet Gynaecol Can. 2004 Aug ;26(8):717-28.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: