Med Pediatr Oncol. 1992;20(1):64-7.

Single institution experience with high-dose cyclophosphamide, continuous infusion vincristine, escalating doses of VP-16-213, and total body irradiation with unpurged bone marrow rescue in children with neuroblastoma.

Source

Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock 72205.

Abstract

Seven consecutive autologous bone marrow transplants were performed in children with neuroblastoma with very good partial remission (VGPR). A combination of cyclophosphamide, escalating doses of VP-16-213, continuous infusion vincristine, and total body irradiation followed by infusion with unpurged bone marrow was used. The dose-limiting toxicity in this regimen was mucositis which occurred when the total dose of VP-16-213 was 2,400 mg/m2. The response rate to this regimen was 4/7 (-CR 48+, 21+, 21+, 35+ mo) 3/7 had a CP/PR post transplant with progressive disease between 1 and 4 months later (mean 2.6 mo). We conclude that this regimen is well tolerated when the maximum dose of VP-16-213 does not exceed 1,800 mg/m2. Further evaluation will be necessary with this regimen to determine its therapeutic value in a larger number of patients with neuroblastoma.

PMID:: 1530757; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

COS Scholar Universe

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Phase I study of high-dose continuous intravenous infusion of VP-16 in combination with high-dose melphalan followed by autologous bone marrow transplantation in children with stage IV neuroblastoma. [Bone Marrow Transplant. 1996]
Phase I study of high-dose continuous intravenous infusion of VP-16 in combination with high-dose melphalan followed by autologous bone marrow transplantation in children with stage IV neuroblastoma.
Valteau-Couanet D, Vassal G, Pondarré C, Bonnay M, Benhamou E, Couanet D, Plantaz D, Hartmann O. Bone Marrow Transplant. 1996 Apr; 17(4):485-9.
[Total body irradiation, vincristine in continuous infusion and high-dose melphalan with transplant of autologous bone marrow in the treatment of neuroblastoma]. [Pediatr Med Chir. 1987]
[Total body irradiation, vincristine in continuous infusion and high-dose melphalan with transplant of autologous bone marrow in the treatment of neuroblastoma].
Dini G, Garaventa A, Lanino E, Perin GP, Scarpati D, Viscoli C, Franchini E, Corvò R, Dallorso S, Cinollo G. Pediatr Med Chir. 1987 Jan-Feb; 9(1):1-7.
A study of thiotepa, etoposide and fractionated total body irradiation as a preparative regimen prior to bone marrow transplantation for poor prognosis patients with neuroblastoma. [Bone Marrow Transplant. 1996]
A study of thiotepa, etoposide and fractionated total body irradiation as a preparative regimen prior to bone marrow transplantation for poor prognosis patients with neuroblastoma.
Kamani N, August CS, Bunin N, Leahey A, Bayever E, Goldwein J, Zusman J, Evans AE, Angio GD. Bone Marrow Transplant. 1996 Jun; 17(6):911-6.
Review Treatment of relapsed aggressive lymphomas: regimens with and without high-dose therapy and stem cell rescue. [Cancer Chemother Pharmacol. 2002]
Review Treatment of relapsed aggressive lymphomas: regimens with and without high-dose therapy and stem cell rescue.
Hagemeister FB. Cancer Chemother Pharmacol. 2002 May; 49 Suppl 1:S13-20. Epub 2002 Apr 12.
Review How effective is dose-intensive/myeloablative therapy against Ewing's sarcoma/primitive neuroectodermal tumor metastatic to bone or bone marrow? The Memorial Sloan-Kettering experience and a literature review. [J Clin Oncol. 2001]
Review How effective is dose-intensive/myeloablative therapy against Ewing's sarcoma/primitive neuroectodermal tumor metastatic to bone or bone marrow? The Memorial Sloan-Kettering experience and a literature review.
Kushner BH, Meyers PA. J Clin Oncol. 2001 Feb 1; 19(3):870-80.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Single institution experience with high-dose cyclophosphamide, continuous infusi...
Single institution experience with high-dose cyclophosphamide, continuous infusion vincristine, escalating doses of VP-16-213, and total body irradiation with unpurged bone marrow rescue in children with neuroblastoma.
Med Pediatr Oncol. 1992 ;20(1):64-7.

PubMed
The prevalence of the human papillomavirus in cervix and vagina in low-risk and ...
The prevalence of the human papillomavirus in cervix and vagina in low-risk and high-risk populations.
Scand J Infect Dis. 2004 ;36(6-7):456-9.

PubMed
A consumer's guide to subgroup analyses.
A consumer's guide to subgroup analyses.
Ann Intern Med. 1992 Jan 1 ;116(1):78-84.

PubMed
[The dynamics of habituation of perception and reaction in tinnitus patients tre...
[The dynamics of habituation of perception and reaction in tinnitus patients treated with TRT].
Otolaryngol Pol. 2004 ;58(2):355-8.

PubMed
Artesunate-atovaquone-proguanil rescue treatment of multidrug-resistant Plasmodi...
Artesunate-atovaquone-proguanil rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report.
Trans R Soc Trop Med Hyg. 2003 Sep-Oct ;97(5):592-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Single institution experience with high-dose cyclophosphamide, continuous infusion vincristine, escalating doses of VP-16-213, and total body irradiation with unpurged bone marrow rescue in children with neuroblastoma.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information