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Clin Infect Dis. 2004 Jul 15;39(2):264-9. Epub 2004 Jun 18.

Increased expression of toll-like receptor 2 on monocytes in HIV infection: possible roles in inflammation and viral replication.

Author information

  • 1Section of Clinical Immunology and Infectious Diseases, Rikshospitalet University Hospital, N-0027, Oslo, Norway. lars.heggelund@klinmed.uio.no

Abstract

BACKGROUND:

Toll-like receptors (TLRs) are key pattern-recognition receptors of the innate immune system, but their role in human immunodeficiency virus (HIV) infection is largely unknown.

METHODS:

In the present study, we examined the expression of TLR2 and TLR4 on monocytes from 48 HIV-infected patients and 21 healthy control subjects by flow cytometry.

RESULTS:

We found that freshly isolated monocytes from HIV-infected patients displayed enhanced expression of TLR2 but not TLR4, that TLR2 expression on the surface of monocytes was significantly increased upon stimulation of HIV type 1 envelope protein gp120, and that TLR2 stimulation in HIV-infected patients induced increased viral replication and TNF- alpha response.

CONCLUSION:

Our findings suggest potential roles for TLR2 in chronic immune activation and viral replication in HIV infection.

PMID:
15307037
[PubMed - indexed for MEDLINE]
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