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Physiology (Bethesda). 2004 Aug;19:225-30.

Cystic kidney diseases: all roads lead to the cilium.

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  • 1Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.


Cystic kidney disorders are one of the leading causes of end-stage renal disease. Numerous experimental animal models have been used to understand the disease pathogenesis. Recent advancements in this field have provided a surprising finding: that many of the proteins associated with cystic kidney disease localize to a nearly forgotten organelle, the primary cilium.

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