Format

Send to:

Choose Destination
See comment in PubMed Commons below
Physiology (Bethesda). 2004 Aug;19:176-82.

Hydroxylation of HIF-1: oxygen sensing at the molecular level.

Author information

  • 1Program in Vascular Cell Engineering, Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. gsemenza@jhmi.edu

Abstract

The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in PO2 are transduced to effect changes in gene expression.

PMID:
15304631
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk