Toxicon. 2004 Sep 15;44(4):441-59.

Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives.

Gordaliza M, García PA, del Corral JM, Castro MA, Gómez-Zurita MA.

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Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain. mliza@usal.es

Abstract

Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity on several neoplastic cell lines. Chemical transformations performed on these compounds have yielded derivatives more potent and more selective that the parent compound. Most of the compounds maintained their cytotoxicity at the microM level. Distribution, biosynthesis, production, biotechnology, applications and synthesis have also been reviewed.

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