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J Cancer Res Clin Oncol. 2004 Nov;130(11):664-70.

The impact of comorbidity on the survival of postmenopausal women with breast cancer.

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  • 1Comprehensive Cancer Center/Field study Breast CAncer, Friedrich-Schiller-University, Jena, Germany.



The aim was to assess the impact of comorbidity on survival of postmenopausal women with breast cancer diagnosis in the period 1995-1997.


The level of comorbidity was described by the methods suggested by Satariano and Charlson. Cox's proportional hazard models were used to explore the impact of comorbidity on all-cause mortality.


After a median follow-up time of 52 months, an increasing level of comorbidity was associated with a higher all-cause mortality. Compared to patients with-out comorbid conditions, the hazard ration of death (HR) was 1.2 (95% CI: 0.8-1.7) for Satariano index 1 and HR 2.3 (95% CI: 1.5-3.5) for Satariano index >or=2, and HR 1.6 and 2.1 for the Charlson comorbidity index, respectively. Independent of comorbidity, the treatment pattern had a strong impact on survival. The level of comorbidity has an influence on the 3-year survival of postmenopausal women with breast cancer.


Long-term follow-up is required to appraise these findings in relation to treatment strategies.

[PubMed - indexed for MEDLINE]
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