Nat Med. 2004 Jul;10 Suppl:S51-7.

Back to the future: the 'old-fashioned' way to new medications for neurodegeneration.

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Harvard Center for Neurodegeneration and Repair and the Department of Neurology, Harvard Medical School, Center for Neurologic Diseases, Brigham and Women's Hospital, 65 Landsdowne St., Cambridge, Massachusetts 02139, USA. plansbury@rics.bwh.harvard.edu

Abstract

Despite the increasing prevalence of Alzheimer's disease, Parkinson's disease and less common neurodegenerative diseases-and despite the large amount of primary research that has been carried out into the causes and pathogenic features of these conditions-progress toward effective treatments has been remarkably slow. Why is this, and what can be done to accelerate it? There are a number of obstacles to effective drug discovery for neurodegeneration, but by considering these problems it is possible to identify lessons for the future.

PMID:: 15298008; [PubMed - indexed for MEDLINE]

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Back to the future: the 'old-fashioned' way to new medications for neurodegenera...
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Nat Med. 2004 Jul ;10 Suppl:S51-7.

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