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    Science. 2004 Oct 1;306(5693):124-9. Epub 2004 Aug 5.

    SRC mediates a switch from microtubule- to actin-based motility of vaccinia virus.

    Newsome TP, Scaplehorn N, Way M.

    Source

    Cell Motility Laboratory, Room 529, Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

    Abstract

    The cascade of events that leads to vaccinia-induced actin polymerization requires Src-dependent tyrosine phosphorylation of the viral membrane protein A36R. We found that a localized outside-in signaling cascade induced by the viral membrane protein B5R is required to potently activate Src and induce A36R phosphorylation at the plasma membrane. In addition, Src-mediated phosphorylation of A36R regulated the ability of virus particles to recruit and release conventional kinesin. Thus, Src activity regulates the transition between cytoplasmic microtubule transport and actin-based motility at the plasma membrane.

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    PMID:
    15297625
    [PubMed - indexed for MEDLINE]

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