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    J Immunol. 2004 Aug 15;173(4):2571-7.

    c-Fos as a regulator of degranulation and cytokine production in FcepsilonRI-activated mast cells.

    Lee YN, Tuckerman J, Nechushtan H, Schutz G, Razin E, Angel P.

    Source

    Department of Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, Israel.

    Abstract

    The AP-1 complex is composed of c-Jun and c-Fos and is a key component in the regulation of proinflammatory genes. Mast cells play a significant role in the initiation of many inflammatory responses, such as allergy and allergy-associated diseases. In the present work, we characterized the role of c-Fos in mast cell function by investigating IL-3-dependent cell proliferation, degranulation capability, and cytokine expression in c-Fos-deficient mice. In c-Fos-deficient mast cells, we found that FcepsilonRI-mediated degranulation was significantly inhibited, which correlates with the reduced expression of SWAP-70, VAMP-7, and Synaptotagmin I genes, which are involved directly in the degranulation process. These findings show that c-Fos plays an important role in FcepsilonRI-mediated regulation of mast cell function.

    PMID:
    15294973
    [PubMed - indexed for MEDLINE]
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