Your browser version may not work well with NCBI's Web applications. More information here...
1: Oral Oncol. 2004 Sep;40(8):856-8.Click here to read Links

Keratosis follicularis of the oral mucosa with oral squamous cell carcinoma.

Dolci M, Favia G, Scully C, Di Alberti L.

Maxillofacial Surgery Section, University of Chieti, Italy.

Darier's disease or keratosis follicularis is a genodermatosis which may involve the oral mucosa. Malignant degeneration is rare. We report the first case of the combined manifestation of oral keratosis follicularis and oral squamous cell carcinoma and discuss the possible involvement of ATP2A2 (located in 12q23-24.1) which encodes the sarco/endoplasmic reticulum Ca(2+)-ATP isoform 2 (SERCA2), in the pathogenesis.

PMID: 15288843 [PubMed - indexed for MEDLINE]