Lancet Infect Dis. 2004 Aug;4(8):510-8.

Immunogenicity and efficacy of childhood vaccines in HIV-1-infected children.

Source

Division of Pediatric Infectious Diseases, Rhode Island Hospital, Department of Pediatrics, Brown Medical School, Providence, RI 02903, USA. sobaro@lifespan.org

Abstract

Children infected by HIV-1 are particularly vulnerable to severe, recurrent, or unusual infections by vaccine-preventable pathogens. Routine immunisations seem to be generally safe for HIV-1-infected children, but responses may be suboptimal. Early HIV-1-induced immune attrition associated with viral replication may particularly interfere with the development of memory responses. In high HIV-1 prevalence regions, the accumulation of susceptible hosts may compromise disease-control efforts. Although early control of viral replication through treatment with highly active therapy may preserve immune function and responses to routine childhood vaccines, availability is limited in the areas most affected. In this review, we provide an overview of the immunogenicity and efficacy of childhood vaccines in HIV-1-infected children. The possible immunological bases for defective responses are discussed; unanswered questions and the need for further research are delineated.

PMID:: 15288824; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Related citations

Review Immunizations in HIV-infected adults. [AIDS Rev. 2007]
Review Immunizations in HIV-infected adults.
Rivas P, Herrero MD, Puente S, Ramírez-Olivencia G, Soriano V. AIDS Rev. 2007 Jul-Sep; 9(3):173-87.
Review Immunization for persons infected with human immunodeficiency virus. [Curr HIV Res. 2004]
Review Immunization for persons infected with human immunodeficiency virus.
Pancharoen C, Ananworanich J, Thisyakorn U. Curr HIV Res. 2004 Oct; 2(4):293-9.
Review Immunization of children at risk of infection with human immunodeficiency virus. [Bull World Health Organ. 2003]
Review Immunization of children at risk of infection with human immunodeficiency virus.
Moss WJ, Clements CJ, Halsey NA. Bull World Health Organ. 2003; 81(1):61-70. Epub 2003 Mar 11.
Varicella vaccination in HIV-1-infected children after immune reconstitution. [AIDS. 2006]
Varicella vaccination in HIV-1-infected children after immune reconstitution.
Bekker V, Westerlaken GH, Scherpbier H, Alders S, Zaaijer H, van Baarle D, Kuijpers T. AIDS. 2006 Nov 28; 20(18):2321-9.
Review Immunization in patients with HIV infection: are practical recommendations possible? [Drugs. 2008]
Review Immunization in patients with HIV infection: are practical recommendations possible?
Eley B. Drugs. 2008; 68(11):1473-81.

See reviews... See all...

Cited by 6 PubMed Central articles

Phase I/II, open-label trial of safety and immunogenicity of meningococcal (groups A, C, Y, and W-135) polysaccharide diphtheria toxoid conjugate vaccine in human immunodeficiency virus-infected adolescents. [Pediatr Infect Dis J. 2010]
Phase I/II, open-label trial of safety and immunogenicity of meningococcal (groups A, C, Y, and W-135) polysaccharide diphtheria toxoid conjugate vaccine in human immunodeficiency virus-infected adolescents.
Siberry GK, Williams PL, Lujan-Zilbermann J, Warshaw MG, Spector SA, Decker MD, Heckman BE, Demske EF, Read JS, Jean-Philippe P, et al. Pediatr Infect Dis J. 2010 May; 29(5):391-6.
Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination. [Vaccine. 2010]
Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination.
Mehta N, Cunningham CK, Flynn P, Pepe J, Obaro S, Kapogiannis BG, Bethel J, Luzuriaga K, Adolescent Trials Network for HIV/AIDS Interventions. Vaccine. 2010 May 7; 28(21):3672-8. Epub 2010 Mar 28.
Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children. [Proc Natl Acad Sci U S A. 2009]
Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children.
Pensieroso S, Cagigi A, Palma P, Nilsson A, Capponi C, Freda E, Bernardi S, Thorstensson R, Chiodi F, Rossi P. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7939-44. Epub 2009 Apr 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Immunogenicity and efficacy of childhood vaccines in HIV-1-infected children.
Immunogenicity and efficacy of childhood vaccines in HIV-1-infected children.
Lancet Infect Dis. 2004 Aug ;4(8):510-8.

PubMed
Nodular scleroderma: increased expression of connective tissue growth factor.
Nodular scleroderma: increased expression of connective tissue growth factor.
Dermatology. 2005 ;211(3):218-23.

PubMed
Very slow EEG fluctuations predict the dynamics of stimulus detection and oscill...
Very slow EEG fluctuations predict the dynamics of stimulus detection and oscillation amplitudes in humans.
J Neurosci. 2008 Aug 13 ;28(33):8268-72.

PubMed
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory ...
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells.
Nat Med. 2009 Jul ;15(7):808-13. Epub 2009 Jun 14 .

PubMed
Confirmation and extension of association of blood lead with attention-deficit/h...
Confirmation and extension of association of blood lead with attention-deficit/hyperactivity disorder (ADHD) and ADHD symptom domains at population-typical exposure levels.
J Child Psychol Psychiatry. 2010 Jan ;51(1):58-65. Epub 2009 Nov 23 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Immunogenicity and efficacy of childhood vaccines in HIV-1-infected children.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Related citations

Cited by 6 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information