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J Hepatol. 2004 Aug;41(2):307-11.

Evaluation of donor hepatic iron concentration as a factor of early fibrotic progression after liver transplantation.

Author information

  • 1Liver Transplantation Unit, DPMSC, University of Udine, Udine, Italy.

Abstract

BACKGROUND/AIMS:

Hepatic iron may act as an important co-morbid factor in non-hemochromatotic liver diseases, but whether it may favour fibrogenesis after liver transplantation is not known. To verify whether the hepatic iron concentration of the graft might play a role in the rapid fibrotic progression frequently observed after liver transplantation for chronic hepatitis C.

METHODS:

The hepatic iron concentration, measured at the time of the donor operation, was retrospectively related to the histological follow-up data of 68 recipients (49 males, 19 females), of whom 38 were hepatitis C virus positive.

RESULTS:

The hepatic iron concentration in donor liver biopsies ranged from 25 to 7,100 microg/gdw. After a median follow-up of 19 months, nine patients (five HCV positive) had a staging score >3. There was a significant association between a higher frequency of increasing staging and donor age >50 years. In female HCV-positive recipients, a graft hepatic iron concentration >1,200 microg/gdw was associated with fibrosis progression >0.15 fibrosis units per month (4/4 vs. 1/7, p<0.01).

CONCLUSIONS:

The graft hepatic iron concentration may be one of the factors involved in early fibrosis progression due to recurrent hepatitis C in female recipients.

PMID:
15288481
[PubMed - indexed for MEDLINE]
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