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Genome Biol. 2004;5(8):R57. Epub 2004 Jul 21.

Modular decomposition of protein-protein interaction networks.

Author information

  • 1Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany. julien.gagneur@cellzome.com

Abstract

We introduce an algorithmic method, termed modular decomposition, that defines the organization of protein-interaction networks as a hierarchy of nested modules. Modular decomposition derives the logical rules of how to combine proteins into the actual functional complexes by identifying groups of proteins acting as a single unit (sub-complexes) and those that can be alternatively exchanged in a set of similar complexes. The method is applied to experimental data on the pro-inflammatory tumor necrosis factor-alpha (TNF-alpha)/NFkappaB transcription factor pathway.

PMID:
15287979
[PubMed - indexed for MEDLINE]
PMCID:
PMC507882
Free PMC Article

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