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Modular decomposition of protein-protein interaction networks.
Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany. julien.gagneur@cellzome.com
We introduce an algorithmic method, termed modular decomposition, that defines the organization of protein-interaction networks as a hierarchy of nested modules. Modular decomposition derives the logical rules of how to combine proteins into the actual functional complexes by identifying groups of proteins acting as a single unit (sub-complexes) and those that can be alternatively exchanged in a set of similar complexes. The method is applied to experimental data on the pro-inflammatory tumor necrosis factor-alpha (TNF-alpha)/NFkappaB transcription factor pathway.
PMID: 15287979 [PubMed - indexed for MEDLINE]
PMCID: PMC507882
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Cited by 13 PubMed Central articles
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Hypergraphs and cellular networks.
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[PLoS Comput Biol. 2009]
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[PLoS Comput Biol. 2008]
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Modular co-evolution of metabolic networks.
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[BMC Bioinformatics. 2007]
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