A direct, efficient method for the preparation of n6-protected 15n-labeled adenosines

J Org Chem. 2004 Aug 6;69(16):5473-5. doi: 10.1021/jo049490u.

Abstract

N6-Protected adenosines have been prepared from inosines by activation of the C6 position and Pd-catalyzed coupling with amides. An efficient route to [6-15NH2]-N6-benzoyladenosine and [1-15N,6-15NH2]-N6-benzoyladenosine has been achieved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemical synthesis*
  • Amides / chemistry
  • Catalysis
  • Indicators and Reagents
  • Inosine / chemistry*
  • Nitrogen Isotopes
  • Palladium / chemistry*

Substances

  • Amides
  • Indicators and Reagents
  • Nitrogen Isotopes
  • Inosine
  • Palladium
  • Adenosine