Nat Biotechnol. 2004 Aug;22(8):1035-6.

Where did the BLOSUM62 alignment score matrix come from?

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Howard Hughes Medical Institute & Department of Genetics, Washington University School of Medicine, 4444 Forest Park Blvd., Box 8510, Saint Louis, Missouri 63108, USA. eddy@genetics.wustl.edu

Abstract

Many sequence alignment programs use the BLOSUM62 score matrix to score pairs of aligned residues. Where did BLOSUM62 come from?

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