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    Science. 2004 Jul 30;305(5684):671-3.

    The complete genome sequence of Propionibacterium acnes, a commensal of human skin.

    Brüggemann H, Henne A, Hoster F, Liesegang H, Wiezer A, Strittmatter A, Hujer S, Dürre P, Gottschalk G.

    Source

    Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Göttingen, Grisebachstrasse 8, 37077 Göttingen, Germany. hbruegg@pasteur.fr

    Abstract

    Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes-associated diseases.

    PMID:
    15286373
    [PubMed - indexed for MEDLINE]
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