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    Science. 2004 Jul 30;305(5684):645.

    APOBEC-mediated editing of viral RNA.

    Bishop KN, Holmes RK, Sheehy AM, Malim MH.

    Source

    Department of Infectious Diseases, Guy's, King's and St. Thomas' School of Medicine, King's College London, London, SE1 9RT, UK.

    Abstract

    Retroviral DNA can be subjected to cytosine-to-uracil editing through the action of members of the APOBEC family of cytidine deaminases. Here we demonstrate that APOBEC-mediated cytidine deamination of human immunodeficiency virus (HIV) virion RNA can also occur. We speculate that the natural substrates of the APOBEC enzymes may extend to RNA viruses that do not replicate through DNA intermediates. Thus, cytosine-to-uracil editing may contribute to the sequence diversification of many viruses.

    PMID:
    15286366
    [PubMed - indexed for MEDLINE]

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