Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biochem Cell Biol. 2004 Aug;82(4):490-7.

New twists on H2A.Z: a histone variant with a controversial structural and functional past.

Author information

  • 1Department of Biochemistry and Microbiology, University of Victoria, BC, Canada.

Abstract

Integration of histone variants into chromatin organization allows for functional specification of chromatin regions. Recent functional analyses of H2A.Z have ascribed to it a multiplicity of complex and often opposing roles in developmental and homeostatic regulation. However, although the manner in which this essential histone variant is able to mediate its effects is not entirely well understood, current work has sought to investigate its mode of action. It is becoming increasingly clear that H2A.Z does not necessarily act independently, but rather, in conjunction with trans-acting factors to elicit chromatin changes. The nature of these structural changes has remained somewhat controversial but nevertheless exemplifies the seemingly multifaceted nature of H2A.Z.

PMID:
15284902
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Atypon
    Loading ...
    Write to the Help Desk