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Bioinformatics. 2004 Dec 12;20(18):3604-12. Epub 2004 Jul 29.

Discovering patterns to extract protein-protein interactions from full texts.

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  • 1State Key Laboratory of Intelligent Technology and Systems, Department of Computer Science and Technology, University of Tsinghua, Beijing, 100084, China.



Although there are several databases storing protein-protein interactions, most such data still exist only in the scientific literature. They are scattered in scientific literature written in natural languages, defying data mining efforts. Much time and labor have to be spent on extracting protein pathways from literature. Our aim is to develop a robust and powerful methodology to mine protein-protein interactions from biomedical texts.


We present a novel and robust approach for extracting protein-protein interactions from literature. Our method uses a dynamic programming algorithm to compute distinguishing patterns by aligning relevant sentences and key verbs that describe protein interactions. A matching algorithm is designed to extract the interactions between proteins. Equipped only with a dictionary of protein names, our system achieves a recall rate of 80.0% and precision rate of 80.5%.


The program is available on request from the authors.

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