Am J Hematol. 2004 Aug;76(4):389-94.

Donor cell myelodysplastic syndrome after allogeneic stem cell transplantation responding to donor lymphocyte infusion: case report and literature review.

Komrokji R, Ifthikharuddin JJ, Felgar RE, Abboud CN, Wedow LA, Connaughton A, Bennett JM.

Source

Department of Medicine, University of Rochester School of Medicine and Dentistry and James P. Wilmot Cancer Center, Rochester, New York 14642, USA. rami_komrokji@urmc.rochester.edu

Abstract

Allogeneic hematopoietic stem cell transplantation (SCT) is a potentially curative treatment for patients with myelodysplastic syndrome (MDS). Relapses after transplantation however, are not uncommon and are usually due to re-emergence of a recipient derived, neoplastic, stem cell clone. We report a unique case of MDS recurring 5 months after non-myeloablative, sibling, allogeneic SCT. Interestingly, chimerism analysis at relapse showed hematopoiesis to be entirely of donor origin confirming donor cell MDS. Donor lymphocyte infusion (DLI) produced a hematological response lasting several months. Our review of the literature shows donor-derived MDS to be very rare, with only four such cases described previously. In this report, we describe the details of our case and discuss putative mechanisms underlying the genesis of donor cell MDS and the observed response to DLI.

PMID:: 15282676; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Improved outcome for peripheral blood stem cell transplantation for advanced primary myelodysplastic syndrome. [Biol Blood Marrow Transplant. 2005]
Improved outcome for peripheral blood stem cell transplantation for advanced primary myelodysplastic syndrome.
Solomon SR, Savani BN, Childs R, Montero A, Boss C, Read EJ, Leitman SF, Barrett AJ. Biol Blood Marrow Transplant. 2005 Aug; 11(8):619-26.
Late diversification in the clonal composition of human cytomegalovirus-specific CD8+ T cells following allogeneic hemopoietic stem cell transplantation. [Blood. 2003]
Late diversification in the clonal composition of human cytomegalovirus-specific CD8+ T cells following allogeneic hemopoietic stem cell transplantation.
Gandhi MK, Wills MR, Okecha G, Day EK, Hicks R, Marcus RE, Sissons JG, Carmichael AJ. Blood. 2003 Nov 1; 102(9):3427-38. Epub 2003 Jul 17.
The effect of donor leukocyte infusion on refractory pure red blood cell aplasia after allogeneic stem cell transplantation in a patient with myelodysplastic syndrome developing from Kostmann syndrome. [Int J Hematol. 2007]
The effect of donor leukocyte infusion on refractory pure red blood cell aplasia after allogeneic stem cell transplantation in a patient with myelodysplastic syndrome developing from Kostmann syndrome.
Ebihara Y, Manabe A, Tsuruta T, Ishikawa K, Hasegawa D, Ohtsuka Y, Kawasaki H, Ogami K, Wada Y, Kanda T, et al. Int J Hematol. 2007 Dec; 86(5):446-50.
Review Alloreactivity as therapeutic principle in the treatment of hematologic malignancies. Studies of clinical and immunologic aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. [Dan Med Bull. 2007]
Review Alloreactivity as therapeutic principle in the treatment of hematologic malignancies. Studies of clinical and immunologic aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning.
Petersen SL. Dan Med Bull. 2007 May; 54(2):112-39.
Review Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review. [Int J Hematol. 2008]
Review Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review.
Murata M, Ishikawa Y, Ohashi H, Terakura S, Ozeki K, Kiyoi H, Naoe T. Int J Hematol. 2008 Jul; 88(1):111-5. Epub 2008 May 10.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Donor cell myelodysplastic syndrome after allogeneic stem cell transplantation r...
Donor cell myelodysplastic syndrome after allogeneic stem cell transplantation responding to donor lymphocyte infusion: case report and literature review.
Am J Hematol. 2004 Aug ;76(4):389-94.

PubMed
Sexually antagonistic selection, sexual dimorphism, and the resolution of intral...
Sexually antagonistic selection, sexual dimorphism, and the resolution of intralocus sexual conflict.
Am Nat. 2009 Feb ;173(2):176-87.

PubMed
Treatment of ADHD in children with tics: a randomized controlled trial.
Treatment of ADHD in children with tics: a randomized controlled trial.
Neurology. 2002 Feb 26 ;58(4):527-36.

PubMed
Gabapentin, estrogen, and placebo for treating hot flushes: a randomized control...
Gabapentin, estrogen, and placebo for treating hot flushes: a randomized controlled trial.
Obstet Gynecol. 2006 Jul ;108(1):41-8.

PubMed
Epistatic and cytonuclear interactions govern outbreeding depression in the auto...
Epistatic and cytonuclear interactions govern outbreeding depression in the autotetraploid Campanulastrum americanum.
Evolution. 2007 Nov ;61(11):2671-83. Epub 2007 Oct 1 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Donor cell myelodysplastic syndrome after allogeneic stem cell transplantation responding to donor lymphocyte infusion: case report and literature review.

Source

Abstract

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information