Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Thorax. 2004 Aug;59(8):713-21.

Acute effects of cigarette smoke on inflammation and oxidative stress: a review.

Author information

  • 1Department of Pulmonology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. H.van.der.vaart@int.azg.nl

Abstract

Compared with the effects of chronic smoke exposure on lung function and airway inflammation, there are few data on the acute effects of smoking. A review of the literature identified 123 studies investigating the acute effects of cigarette smoking on inflammation and oxidative stress in human, animal, and in vitro models. An acute smoking model is a relatively easy and sensitive method of investigating the specific effects of cigarette smoke on oxidative stress and inflammation. Acute smoke exposure can result in tissue damage, as suggested by increased products of lipid peroxidation and degradation products of extracellular matrix proteins. Acute cigarette smoke has a suppressive effect on the number of eosinophils and several inflammatory cytokines, possibly due to the anti-inflammatory effect of carbon monoxide. An acute smoking model can supplement other ways of studying the effects of smoking and is an as yet underinvestigated method for intervention studies in smoking related diseases.

PMID:
15282395
[PubMed - indexed for MEDLINE]
PMCID:
PMC1747102
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk