Conditioning trials that are massed in time produce less conditioning than those that are spaced in time. Four experiments with rat subjects examined whether a recent conditioning trial interferes with conditioning on the next trial by temporarily "priming" information in short-term memory (e.g., Wagner, 1978, 1981). We used appetitive conditioning procedures in which priming trials preceded target trials by 60 sec. When the priming trials were nonreinforced presentations of a conditioned stimulus (CS), the CS had to be the same CS as the one on the target trial to interfere with conditioning. When priming trials were actual CS-unconditioned stimulus (US) pairings, the CS identity did not matter, the US was the event that interfered with conditioning on the next trial. Reinforced trials reduced performance in a way that did not depend on context blocking. The results suggest that CS and US priming effects do contribute to conditioning deficits observed with massed trial procedures. The results are consistent with Wagner's (1981) "sometimes opponent process," or SOP, model, although a result that is paradoxical for the model suggests that recent USs may have motivational as well as memory effects.