Send to:

Choose Destination
See comment in PubMed Commons below
DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1033-7.

Claspin, a regulator of Chk1 in DNA replication stress pathway.

Author information

  • 1Department of Oncology, Mayo Clinic and Foundation, Rochester, MN 55902, USA.


Regulation of the vertebrate checkpoint kinase Chk1 involves several protein complexes including the recently identified protein Claspin. Claspin associates with Chk1 upon replication stress and DNA damage and is required for Chk1 activation in both Xenopus and human systems. More importantly, Claspin is involved in regulation of cell cycle checkpoints. Here, we discuss the emerging roles of Claspin in the Chk1 pathway and its functions in checkpoint control.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk