Biochim Biophys Acta. 2004 Aug 4;1689(3):175-8.

Interaction of ACE2 and integrin beta1 in failing human heart.

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The Center for Functional Genomics, Proteomics Core Facility, University at Albany, Rensselaer, NY, USA.

Abstract

ACE2 purified from failing human heart was found to form a complex with integrin beta1 by immunoprecipitation, Western blotting, activity assay, and ESI tandem mass spectroscopy. The ACE2/integrin complex showed a Km of 6.8 microM and a Vmax of 2.13 pmol/min/microl purified enzyme. Activity was optimal at pH 7.5 with Ang II substrate.

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Cited by 1 PubMed Central article

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