Format

Send to

Choose Destination
See comment in PubMed Commons below
Parasitol Today. 1996 Nov;12(11):442-4.

Malaria and the cell cycle.

Author information

  • 1Department of Medicine, Infectious Diseases Section, University of Pennsylvania, Philadelphia, PA 19104-6073, USA.

Abstract

The current model of cell cycle control features a succession of active cyclin-CDK (cyclin-dependent kinase) complexes, where accumulation of each successive cyclin leads to activation of its associated kinase. Cell fusion experiments have shown that nuclei sharing common cytoplasm progress through the cell cycle in synchrony. During schizogony of Plasmodium falciparum, nuclear division occurs asynchronously, and thus cannot be regulated by synthesis and accumulation of cyclins in the cytoplasm. We suggest that schizonts must have a ready pool of cyclins for activating all stages of the cycle, and that the cell cycle is regulated independently in each nucleus.

Comment in

PMID:
15275278
[PubMed]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk