Effect of Noolit, a novel lithium preparation, on electrophysiological activity of rat cerebral cortex

N I Suslov; A A Fedorov; O V Pershina; Yu I Borodin; L N Rachkovskaya

doi:10.1023/b:bebm.0000028128.18241.51

Effect of Noolit, a novel lithium preparation, on electrophysiological activity of rat cerebral cortex

Bull Exp Biol Med. 2004 Feb;137(2):155-8. doi: 10.1023/b:bebm.0000028128.18241.51.

[Article in English, Russian]

Authors

N I Suslov¹, A A Fedorov, O V Pershina, Yu I Borodin, L N Rachkovskaya

Affiliation

¹ Institute of Pharmacology, Tomsk Research Center; Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.

PMID: 15273763
DOI: 10.1023/b:bebm.0000028128.18241.51

Abstract

The effects of lithium carbonate and Noolit, a novel lithium enterosorbent, on electrophysiological activity of cerebral cortex in rats were compared. Both agents potentiated the theta-, alpha-, and beta-rhythms and modified the response to rhythmic flash stimulation from potentiation to inhibition of cerebral rhythms. Moreover, these drugs increased dispersion of all rhythms. By contrast to lithium carbonate, the effect of Noolit was milder and developed more slowly.

Publication types

Comparative Study

MeSH terms

Alpha Rhythm / drug effects
Animals
Antidepressive Agents / pharmacology*
Beta Rhythm / drug effects
Cerebral Cortex / drug effects*
Cerebral Cortex / physiology*
Delta Rhythm / drug effects
Electrophysiology
Lithium / pharmacology*
Lithium Carbonate / pharmacology
Male
Rats

Substances

Antidepressive Agents
noolith
Lithium Carbonate
Lithium