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Antimicrob Agents Chemother. 2004 Aug;48(8):3141-6.

Lack of evidence that DNA in antibiotic preparations is a source of antibiotic resistance genes in bacteria from animal or human sources.

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  • 1Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.


Although DNA encoding antibiotic resistance has been discovered in antibiotic preparations, its significance for the development of antibiotic resistance in bacteria is unknown. No phylogenetic evidence was obtained for recent horizontal transfer of antibiotic resistance genes from antibiotic-producing organisms to bacteria from human or animal sources.

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