J Clin Psychopharmacol. 1992 Aug;12(4):268-72.

Central nervous system stimulants as symptomatic treatments for AIDS-related neuropsychiatric impairment.

Angrist B, d'Hollosy M, Sanfilipo M, Satriano J, Diamond G, Simberkoff M, Weinreb H.

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New York DVA Medical Center, NY 10010.

Abstract

Seven patients with AIDS-related cognitive and emotional deficits had neuropsychologic testing and then were treated with methylphenidate or dextroamphetamine in individualized doses. Three patients showed marked functional improvement and 5 of the 7 became more spontaneous, reactive, and animated. Additional neuropsychologic testing showed statistically significant improvement in a subset of tests; however, scores did not return to baseline in tests done after the treatment was discontinued for 1-3 days.

PMID:: 1527230; [PubMed - indexed for MEDLINE]

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