J Clin Psychopharmacol. 1992 Aug;12(4):241-5.

Antidepressants and convulsions.

Source

Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, Massachusetts 02173.

Abstract

We reviewed available computer records and clinical charts in an estimated 42,000 recipients of antidepressant drugs. The study was restricted to persons with no known condition predisposing to convulsions. Only 16 study subjects developed a convulsive disorder that we judged could have been caused by an antidepressant. We conclude that the frequency of convulsions caused by these drugs used at usual prescribed doses in the settings studied is substantially less than one per 1,000 recipients who have no conditions predisposing to convulsions.

PMID:: 1527226; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Antidepressive Agents

Grant Support

FD-U-000071-10/FD/FDA HHS/United States

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Medical

Supplemental Content

Save items

Related citations in PubMed

Review Incidence of seizures during treatment with tricyclic antidepressant drugs and bupropion. [J Clin Psychiatry. 1983]
Review Incidence of seizures during treatment with tricyclic antidepressant drugs and bupropion.
Peck AW, Stern WC, Watkinson C. J Clin Psychiatry. 1983 May; 44(5 Pt 2):197-201.
Seizures and myoclonus associated with antidepressant treatment: assessment of potential risk factors, including CYP2D6 and CYP2C19 polymorphisms, and treatment with CYP2D6 inhibitors. [Acta Psychiatr Scand. 1997]
Seizures and myoclonus associated with antidepressant treatment: assessment of potential risk factors, including CYP2D6 and CYP2C19 polymorphisms, and treatment with CYP2D6 inhibitors.
Spigset O, Hedenmalm K, Dahl ML, Wiholm BE, Dahlqvist R. Acta Psychiatr Scand. 1997 Nov; 96(5):379-84.
Review Seizures with neuroleptics and antidepressants. [Gen Hosp Psychiatry. 1987]
Review Seizures with neuroleptics and antidepressants.
Markowitz JC, Brown RP. Gen Hosp Psychiatry. 1987 Mar; 9(2):135-41.
Review Seizures associated with antidepressants: a review. [J Clin Psychiatry. 1993]
Review Seizures associated with antidepressants: a review.
Rosenstein DL, Nelson JC, Jacobs SC. J Clin Psychiatry. 1993 Aug; 54(8):289-99.
Antidepressants and the risk of suicidal behaviors. [JAMA. 2004]
Antidepressants and the risk of suicidal behaviors.
Jick H, Kaye JA, Jick SS. JAMA. 2004 Jul 21; 292(3):338-43.

See reviews... See all...

Cited by 1 PubMed Central article

Use of selective serotonin reuptake inhibitors and risk of developing first-time acute myocardial infarction. [Br J Clin Pharmacol. 2001]
Use of selective serotonin reuptake inhibitors and risk of developing first-time acute myocardial infarction.
Meier CR, Schlienger RG, Jick H. Br J Clin Pharmacol. 2001 Aug; 52(2):179-84.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Antidepressants and convulsions.
Antidepressants and convulsions.
J Clin Psychopharmacol. 1992 Aug ;12(4):241-5.

PubMed
Facile crystallization of Escherichia coli ketol-acid reductoisomerase.
Facile crystallization of Escherichia coli ketol-acid reductoisomerase.
Acta Crystallogr D Biol Crystallogr. 2004 Aug ;60(Pt 8):1432-4. Epub 2004 Jul 21 .

PubMed
Distinct ensemble codes in hippocampal areas CA3 and CA1.
Distinct ensemble codes in hippocampal areas CA3 and CA1.
Science. 2004 Aug 27 ;305(5688):1295-8. Epub 2004 Jul 22 .

PubMed
Is there any relationship between Chlamydophila pneumoniae infection and juvenil...
Is there any relationship between Chlamydophila pneumoniae infection and juvenile idiopathic arthritis?
J Med Microbiol. 2004 Aug ;53(Pt 8):787-90.

PubMed
Myocardial protection at a crossroads: the need for translation into clinical th...
Myocardial protection at a crossroads: the need for translation into clinical therapy.
Circ Res. 2004 Jul 23 ;95(2):125-34.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: