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Bioinformatics. 2004 Dec 12;20(18):3673-5. Epub 2004 Jul 22.

SelSim: a program to simulate population genetic data with natural selection and recombination.

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  • 1Department of Statistics, 1 South Parks Road, Oxford OX1 3TG, UK. <>


SelSim is a program for Monte Carlo simulation of DNA polymorphism data for a recombining region within which a single bi-allelic site has experienced natural selection. SelSim allows simulation from either a fully stochastic model of, or deterministic approximations to, natural selection within a coalescent framework. A number of different mutation models are available for simulating surrounding neutral variation. The package enables a detailed exploration of the effects of different models and strengths of selection on patterns of diversity. This provides a tool for the statistical analysis of both empirical data and methods designed to detect natural selection.



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