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Curr Biol. 2004 Jul 27;14(14):R565-7.

Telomerase RNA: a flexible RNA scaffold for telomerase biosynthesis.

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  • Department of Biochemistry, Tulane University Heath Sciences Center, New Orleans, Louisiana 70112, USA. alustig@tulane.edu


Determination of the structure of the yeast telomerase RNA component TLC1 has been hampered by its large size and high rate of evolutionary divergence. But detailed phylogenetic comparisons have now revealed the unusually flexible and modular architecture of this important RNA molecule.

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