Int J Clin Pharmacol Ther Toxicol. 1992 Aug;30(8):261-4.

Antiepileptic therapy and teratogenicity in Turkey.

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Department of Pharmacology, Cerrahpaşa Faculty of Medicine, University of Istanbul, Turkey.

Abstract

In this study 170 children born to 116 epileptic mothers are evaluated for the presence of congenital malformations. In one group, the mothers of 104 children were administered with one or more antiepileptic drugs (AEDs) during their pregnancies. In the control group, the mothers of 66 children received no therapy throughout or during the first trimester of their pregnancies. Twelve of the 104 children who were exposed to antiepileptic drugs in utero, had various major congenital malformations. On the other hand, 66 children who were not exposed to AEDs in utero had no malformations. The incidence of congenital malformations in children born to epileptic mothers was found to be significantly higher compared to the incidence observed in other studies (0.48-2%) among the general population of Turkey.

PMID:: 1526687; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Comparative Study

MeSH Terms

Substances

Anticonvulsants

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Medical

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Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy. [Epilepsia. 1997]
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Cited by 1 PubMed Central article

Review Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts. [Epilepsy Res. 2008]
Review Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts.
Meador K, Reynolds MW, Crean S, Fahrbach K, Probst C. Epilepsy Res. 2008 Sep; 81(1):1-13. Epub 2008 Jun 18.

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