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    Am J Med Genet A. 2004 Aug 15;129A(1):83-6.

    Choanal atresia associated with prenatal methimazole exposure: three new patients.

    Barbero P, Ricagni C, Mercado G, Bronberg R, Torrado M.

    Source

    Centro Nacional de Genética Médica, Buenos Aires, Argentina. pablo@genes.gov.ar

    Abstract

    We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in utero. At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus.

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    PMID:
    15266622
    [PubMed - indexed for MEDLINE]

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