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Pediatr Transplant. 2004 Aug;8(4):344-8.

The pediatric nephrotic syndrome spectrum: clinical homogeneity and molecular heterogeneity.

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  • 1Children's Hospital Informatics Program, Division of Nephrology, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.


Idiopathic nephrotic syndrome is the most common glomerular disorder of childhood. Recurrence of nephrotic syndrome immediately following renal transplantation is rapid, results in a high rate of graft loss, and represents the most severe form of nephrotic syndrome. This review discusses the molecular heterogeneity of pediatric nephrotic syndrome across the spectrum of disease activity. A schema is offered for a molecular approach to pediatric nephrotic syndrome, including immune-mediated and structural/genetic factors.

Copyright 2004 Blackwell Munksgaard

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