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Pediatr Transplant. 2004 Aug;8(4):344-8.

The pediatric nephrotic syndrome spectrum: clinical homogeneity and molecular heterogeneity.

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  • 1Children's Hospital Informatics Program, Division of Nephrology, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. asher.schachter@childrens.harvard.edu

Abstract

Idiopathic nephrotic syndrome is the most common glomerular disorder of childhood. Recurrence of nephrotic syndrome immediately following renal transplantation is rapid, results in a high rate of graft loss, and represents the most severe form of nephrotic syndrome. This review discusses the molecular heterogeneity of pediatric nephrotic syndrome across the spectrum of disease activity. A schema is offered for a molecular approach to pediatric nephrotic syndrome, including immune-mediated and structural/genetic factors.

Copyright 2004 Blackwell Munksgaard

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