J Cell Biol. 2004 Jul 19;166(2):157-9.

FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?

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Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599, USA. crispy4@med.unc.edu

Abstract

FAK and paxillin are important components in integrin-regulated signaling. New evidence suggests that these two proteins function in crosstalk between cell-matrix and cell-cell adhesions. Further, new insight suggests that under some conditions these proteins inhibit cell migration, in contrast to their established roles in several cell systems as positive regulators of cell adhesion and migration.

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