Ann Intern Med. 1978 Dec;89(6):945-8.

Calusterone.

Abstract

Androgens are effective therapeutic agents in postmenopausal women with metastatic breast cancer. Early studies with testosterone propionate showed objective regression rates of slightly more than 20%. Subsequent work with synthetic androgens has failed to show a significant reduction in toxicity or an increase in therapeutic efficacy over testosterone propionate. Calusterone (7 beta,17 alpha-dimethyltestosterone), in early clinical trials, showed both of these qualities and was believed by some to be the "ideal androgen." As with many new drugs, subsequent work failed to confirm these early findings, and most of the later data gathered on calusterone are inconsistent. We conclude from our knowledge at present that calusterone offers no real advantages or disadvantages over other androgens in the treatment of breast cancer.

PMID:: 152592; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Methyltestosterone

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Medical

Breast Cancer - MedlinePlus Health Information

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17-METHYLTESTOSTERONE - HSDB

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Related citations in PubMed

[Clinical considerations on the use of a new synthetic androgen, Calusterone, in the treatment of advanced breast cancer]. [Minerva Med. 1977]
[Clinical considerations on the use of a new synthetic androgen, Calusterone, in the treatment of advanced breast cancer].
de Matteis A, Perrone V, Marone A. Minerva Med. 1977 Jul 28; 68(36):2499-504.
Male breast cancer: two cases with objective regressions from calusterone (7 alpha, 17 beta-dimethyltestosterone) after failure of orchiectomy. [Oncology. 1976]
Male breast cancer: two cases with objective regressions from calusterone (7 alpha, 17 beta-dimethyltestosterone) after failure of orchiectomy.
Horn Y, Roof B. Oncology. 1976; 33(4):188-91.
[Calusterone (7-beta, 17-alpha-dimethyltestosterone) in the palliative treatment of advanced breast cancer]. [Minerva Med. 1977]
[Calusterone (7-beta, 17-alpha-dimethyltestosterone) in the palliative treatment of advanced breast cancer].
Robustelli Della Cuna G, Bernardo G, Strada MR. Minerva Med. 1977 Oct 31; 68(52):3555-63.
Review Overview of resistance to systemic therapy in patients with breast cancer. [Adv Exp Med Biol. 2007]
Review Overview of resistance to systemic therapy in patients with breast cancer.
Gonzalez-Angulo AM, Morales-Vasquez F, Hortobagyi GN. Adv Exp Med Biol. 2007; 608:1-22.
Review Safety of estrogen/androgen regimens. [J Reprod Med. 2001]
Review Safety of estrogen/androgen regimens.
Simon JA. J Reprod Med. 2001 Mar; 46(3 Suppl):281-90.

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