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1: Eye. 2005 Mar;19(3):303-7.Click here to read Links

Comparing the effects of travoprost and brinzolamide on intraocular pressure after phacoemulsification.

Ermis SS, Ozturk F, Inan UU.

Department of Ophthalmology, School of Medicine, University of Afyon, Kocatepe, Afyon, Turkey. sametermis@hotmail.com

PURPOSE: To evaluate the intraocular pressure (IOP) lowering effect of travoprost and brinzolamide within the first 24 h after phacoemulsification cataract surgery. METHODS: This prospective, randomized, double-masked, controlled study comprised 90 eyes of 90 consecutive patients with senile cataract who had uneventful phacoemulsification surgery. Eyes in the first group received travoprost 0.0015%, second group received brinzolamide 1%. Eyes in the third group received balanced salt solution and were used as control. One drop was instilled immediately after surgery. IOP was measured 24 h preoperatively, 6 and 24 h postoperatively. Analysis of variance, Student's-t and chi2-tests were used for statistical analyses. RESULTS: Preoperatively IOP was not significantly different among the three groups (P = 0.653). At 6 and 24 h postoperatively IOP was lower in both travoprost and brinzolamide group when compared to control group (P = 0.018 and 0.015 at 6 h, P = 0.010 and 0.007 at 24 h between travoprost and brinzolamide group was not significant (P = 0.744 at 6 h and P = 0.672 at 24 h). CONCLUSION: Both travoprost and brinzolamide significantly lowered IOP after small incision phacoemulsification cataract surgery within the first 24 h without any side effect.

PMID: 15258611 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Travoprost Ophthalmic (Travatan® )

    Travoprost is used to treat eye conditions, including glaucoma and ocular hypertension, in which increased pressure can lead to a gradual loss of vision. Travoprost is used for patients who cannot use other eye medicatio...

  • Brinzolamide Ophthalmic (Azopt® )

    Brinzolamide ophthalmic is used to treat glaucoma, a condition that increases pressure in the eye and leads to vision loss. Brinzolamide ophthalmic is in a class of drugs called carbonic anhydrase inhibitors. It decrease...

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