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Int J Legal Med. 2004 Oct;118(5):267-73.

Artificial recombination in forensic mtDNA population databases.

Author information

  • 1Fachbereich Mathematik, Universit├Ąt Hamburg, Bundesstrasse 55, 20146 Hamburg, Germany. bandelt@math.uni-hamburg.de

Abstract

Artificial recombination of two or more mitochondrial DNA fragments from different samples would constitute a serious cause of error in forensic DNA typing, and yet one can demonstrate that such events have happened in the preparation of several published mtDNA databases. Focussed database searches, phylogenetic analysis, and network representations can highlight mosaic patterns and thus pinpoint sample mix-up. Therefore, we suggest that this approach should be applied to data prior to publication in order to uncover such errors in time.

PMID:
15257464
[PubMed - indexed for MEDLINE]
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