Indian J Exp Biol. 2003 Feb;41(2):181-3.

Effect of methanolic leaf extract of Cissampelos mucronata A. Rich against indomethacin induced ulcer in rats.

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Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria. svnwafor@hotmail.com

Abstract

Five fractions (F1-F5) isolated from the methanolic leaf extract of Cissampelos mucronata A. Rich were investigated for antiulcer activity. At the dose of 450 mg/kg, they showed varying degree of protection against ulcer induced by indomethacin; the order of protection being F1>F4>F5>F2>F3. The antiulcer potency of F1 and F2 is comparable with that of cimetidine (100 mg/kg, i.p.). Inhibition of gastric mucosal damage may partly contribute to the antiulcer activity of the fractions.

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Effect of methanolic leaf extract of Cissampelos mucronata A. Rich against indomethacin induced ulcer in rats.

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