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1: Ther Apher Dial. 2004 Apr;8(2):102-11.Links

Drug-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome: a concise review.

Dlott JS, Danielson CF, Blue-Hnidy DE, McCarthy LJ.

Department of Pathology and Laboratory Medicine (Transfusion Medicine), Indiana University School of Medicine, Indianapolis, IN, USA.

An extensive variety of drugs have been associated with thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (TTP/HUS). Although a direct causal effect has usually not been proven, the cumulative evidence linking several drugs with TTP/HUS is strong. This paper reviews several categories of drugs including antineoplastics, immunotherapeutics and anti-platelet agents that have been reported to induce TTP/HUS. The pathogenesis of drug-induced TTP/HUS and the effectiveness of treatment regimens are also reviewed. A consensus on diagnostic criteria to accurately and consistently diagnose drug-induced TTP is needed.

PMID: 15255125 [PubMed - indexed for MEDLINE]