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J Am Chem Soc. 2004 Jul 21;126(28):8622-3.

Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex.

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  • 1Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, PRESTO, JST, Fukuoka 812-8581, Japan.


We developed a highly enantioselective separation system for the optically active compounds, (S)-ibuprofen and l-phenylalanine, from their racemic mixtures by employing a supported liquid membrane (SLM) encapsulating a surfactant-lipase complex (or a surfactant-alpha-chymotrypsin complex). In the present system, enzymes encapsulated in the liquid-membrane phase effectively drove the enantioselective transport of optically active compounds through the SLM. This novel SLM allowed high enantioselectivity (ee over 91%) in the optical resolution of racemic ibuprofen and phenylalanine.

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