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Nucleic Acids Res. 2004 Jul 9;32(12):3651-60. Print 2004.

A set of BAC clones spanning the human genome.

Author information

  • 1BC Cancer Agency Genome Sciences Center and BC Cancer Agency, Vancouver, BC V5Z 4E6, Canada.

Abstract

Using the human bacterial artificial chromosome (BAC) fingerprint-based physical map, genome sequence assembly and BAC end sequences, we have generated a fingerprint-validated set of 32 855 BAC clones spanning the human genome. The clone set provides coverage for at least 98% of the human fingerprint map, 99% of the current assembled sequence and has an effective resolving power of 79 kb. We have made the clone set publicly available, anticipating that it will generally facilitate FISH or array-CGH-based identification and characterization of chromosomal alterations relevant to disease.

PMID:
15247347
[PubMed - indexed for MEDLINE]
PMCID:
PMC484185
Free PMC Article

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