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1: Toxicon. 2004 Aug;44(2):117-22.Click here to read Click here to read Links

Using the deadly mu-conotoxins as probes of voltage-gated sodium channels.

Li RA, Tomaselli GF.

The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 871, Baltimore, MD 21205, USA. ronaldli@jhmi.edu

Mu-Conotoxins (mu-CTX) are potent Na channel inhibitory peptides isolated from the venom of the predatory marine snail Conus geographus. Mu-CTXs exert their biological action by physically occluding the ion-conducting pore of voltage-gated Na (Na(v)) channels with a 1:1 stoichiometry in an all-or-none fashion. This article reviews our current knowledge of the mechanism of mu-CTX and the associated structural and functional insights into its molecular target--Na(v) channels.

PMID: 15246758 [PubMed - indexed for MEDLINE]

PMCID: PMC2698010