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1: Vaccine. 2004 Jul 29;22(21-22):2881-6.Click here to read Links

CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques.

Klinman DM, Xie H, Little SF, Currie D, Ivins BE.

Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg. 29A, Rm. 3 D 10, Bethesda, MD 20892, USA. klinman@cber.fda.gov

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants, improving the immune response elicited by co-administered vaccines. Combining CpG ODN with anthrax vaccine adsorbed (AVA, the licensed human vaccine) increased the speed, magnitude and avidity of the resultant anti-anthrax response. The protective activity of these Abs was established by passive transfer to anthrax-challenged mice. The ability of CpG ODN to accelerate and magnify the immune response to AVA suggests this strategy may contribute to the development of prophylactic and therapeutic vaccines against biothreat pathogens.

PMID: 15246624 [PubMed - indexed for MEDLINE]

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  • Anthrax Vaccine (Biothrax® )

    Anthrax is a serious disease that can affect both animals and humans. It is caused by bacteria calledBacillus anthracis. People can get anthrax from contact with infected animals, wool, meat, or hides. In its most common...

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