Trends Parasitol. 2004 Aug;20(8):355-8.

Genomics meets transgenics in search of the elusive Cryptosporidium drug target.

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Center for Tropical and Emerging Global Diseases, University of Georgia, 623 Biological Sciences Building, Athens, GA 30602, USA. striepen@cb.uga.edu

Abstract

Cryptosporidium is an important pathogen of humans, and a challenging model for the laboratory. The parasite genome sequence, accessible through a comprehensive database, now provides exciting opportunities for urgently needed advances. Comparative genomics, combined with the genetic system in the related parasite Toxoplasma gondii, outlines a detailed Cryptosporidium parvum metabolic map and facilitates cell biological analyses. New targets for Cryptosporidium drug and vaccine development can be identified and validated based on this approach.

PMID:: 15246316; [PubMed - indexed for MEDLINE]

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